Express Scripts
Express Scripts is a major American pharmacy benefit management and pharmacy services company that helps health plans, employers, government programs and other organizations manage prescription drug benefits. Its services include pharmacy benefit administration, home-delivery pharmacy, retail pharmacy network management, formulary management, medication access programs, specialty pharmacy coordination and other pharmacy-care solutions. Express Scripts currently operates as the pharmacy benefit services business within Evernorth Health Services, which is part of The Cigna Group.
Express Scripts traces its history to 1986 in St. Louis, Missouri, when a health maintenance organization and regional pharmacy chain created a mail-service pharmacy operation. The first 11 prescription orders were processed in February 1987 by a team of only five employees. The company later expanded into pharmacy benefit management and became one of the largest PBMs in the United States. Express Scripts officially became part of Cigna in 2018, when Cigna completed its combination with Express Scripts.
Today, Express Scripts continues to maintain major operations at and around One Express Way in St. Louis, Missouri. The Cigna Group’s latest annual filing specifically identifies the Evernorth Health Services corporate offices at and around One Express Way as one of its principal domestic office locations. Parent company The Cigna Group is headquartered at 900 Cottage Grove Road, Bloomfield, Connecticut 06002 and employed approximately 67,700 people worldwide at the end of 2025. Express Scripts-specific employee totals are not separately disclosed in the current Cigna Group annual report.
+1 (314) 996-0900
Express Scripts historically published 314-996-0900 as the corporate telephone number associated with its One Express Way headquarters in St. Louis.
Because Express Scripts is now part of Evernorth Health Services and The Cigna Group, ordinary members should use the current Patient Customer Service number rather than the former standalone corporate switchboard for prescription-benefit questions.
1-800-282-2881
Express Scripts officially publishes this number for general Patient Customer Service and Express Scripts Pharmacy support.
Service is available:
24 hours a day, 7 days a week
Members can also call the plan-specific number printed on the back of their prescription ID card.
Express Scripts / Evernorth Health Services
One Express Way
St. Louis, MO 63121
United States
The Cigna Group’s current 2025 Form 10-K identifies Evernorth Health Services corporate offices at and around One Express Way in St. Louis, Missouri.
Express Scripts / Evernorth Health Services
One Express Way
St. Louis, Missouri 63121
United States
Express Scripts continues to have a major corporate presence in St. Louis, while the ultimate parent company’s principal executive offices are located in Bloomfield, Connecticut.
Express Scripts does not publish one universal general member-service email for all prescription-benefit questions.Members are encouraged to sign in to their Express Scripts account and use the plan-specific Contact Us options.
Fraud Tip Email: fraudtip@evernorth.com
This address is specifically for suspected fraudulent activity and should not be used for ordinary prescription or account support.
Pharmacy Benefit Management, Pharmacy Services, Home Delivery Pharmacy, Prescription Drug Benefits, Specialty Pharmacy, Health Services and Healthcare Technology
1986
Express Scripts began in St. Louis in 1986 as a mail-service pharmacy operation.The first prescription orders were processed on February 3, 1987.
Express Scripts does not currently report a standalone employee total.Its parent organization, The Cigna Group, employed approximately 67,700 people worldwide at the end of 2025.About 88% of The Cigna Group’s employees were based in the United States.
Express Scripts does not publish standard public walk-in hours for its St. Louis corporate offices.
For members and patients:
Express Scripts Pharmacy Customer Service: 24/7
General Patient Customer Service: 24/7
Website Support: 24/7
Express Scripts
The official website provides prescription-benefit information, home-delivery pharmacy services, account management, claims history, medication information and member support.
Express Scripts is not separately publicly traded.
Its ultimate parent company is The Cigna Group, whose common stock trades on the New York Stock Exchange under ticker symbol CI.
Investor information is provided through The Cigna Group’s investor resources.
Express Scripts and Evernorth career opportunities are managed through The Cigna Group Careers platform.
Roles may include pharmacy, clinical operations, technology, analytics, customer service, healthcare management, finance and corporate functions.
Express Scripts provides pharmacy benefit management services to employers, health plans and other plan sponsors.
The company manages prescription drug benefits with a focus on medication access, affordability, safety and appropriate drug utilization.
Express Scripts Pharmacy by Evernorth provides home-delivery prescription services.
The Cigna Group states that the service offers free standard shipping nationwide and commonly provides medications in 90-day supplies.
Eligible members can have maintenance medications shipped directly to their homes.
Express Scripts operates multiple licensed home-delivery pharmacy facilities across the United States.
Express Scripts manages pharmacy networks that allow members to fill eligible prescriptions at participating retail pharmacies.
Network availability depends on the member’s health plan and prescription benefit.
Express Scripts develops and manages drug formularies for participating health plans.
Formularies are designed to balance clinical effectiveness, safety, member access and medication costs.
Express Scripts processes pharmacy claims for health plans and members.
Members can view eligible claims history by signing in to their Express Scripts account.
Express Scripts Pharmacy provides direct access to pharmacists.
Pharmacists are available 24 hours a day, seven days a week for medication-related questions.
Express Scripts works with specialty pharmacy services through Evernorth’s broader pharmacy-care network.
Accredo Specialty Pharmacy by Evernorth provides specialty medication services for patients with complex and chronic conditions.
Patients can contact Accredo Specialty Pharmacy to get started with eligible specialty medications.
Accredo Number: 1-877-222-7336
Support is available 24/7.
Evernorth EnGuide Pharmacy was established to support patients using GLP-1 medications.
Services focus on medication access, clinical support, dose optimization and pharmacist guidance.
Express Scripts provides pharmacy-benefit support for Medicare members.
Medicare Member Number: 1-866-529-4917
Support is available 24 hours a day, seven days a week.
Express Scripts administers pharmacy support for eligible TRICARE beneficiaries.
TRICARE Customer Service: 1-877-363-1303
Support is available 24/7.
Members can review prescription benefit information through their online accounts.
Available tools can include medication coverage, prescription claims, home-delivery information and plan-specific pharmacy details.
Express Scripts provides online tools for managing prescription benefits.
Members can view claims history, prescriptions, account information and plan-specific support resources.
Express Scripts provides a mobile application for prescription-benefit and pharmacy account management.
Users can access eligible account information, prescriptions and support tools.
Members can view and print prescription claims history through their online account.
Express Scripts states that online claims history can be used for personal records, tax preparation or sharing with healthcare providers.
Express Scripts maintains a Fraud Tip Hotline for suspected fraudulent activity.
Fraud Hotline: 1-866-216-7096
Email: fraudtip@evernorth.com
The hotline operates 24/7.
+1 (314) 996-0900
This was the verified corporate number associated with Express Scripts’ One Express Way headquarters while Express Scripts operated as a standalone reporting company.
For current member support, use:
1-800-282-2881
+1 (314) 996-0900
This number is historically associated with:
One Express Way
St. Louis, MO 63121
The current Cigna Group annual report continues to identify Evernorth Health Services offices at and around One Express Way, although current consumer contacts are routed through dedicated support numbers.
For current member-facing assistance:
1-800-282-2881
Express Scripts does not prominently publish a separate modern corporate switchboard on its current Contact Us page.
+1 (314) 996-0900
This number should be treated as a corporate-location contact rather than the primary prescription-support number.
1-800-282-2881
Express Scripts publishes this number for general Patient Customer Service.
1-800-282-2881
Support is available 24/7.
1-800-282-2881
This is Express Scripts’ primary verified general toll-free member-support number.
1-800-711-5672
This number is for technical assistance involving Express Scripts online accounts and website access.
Support is available 24/7.
1-866-529-4917
This number is specifically for Medicare prescription-benefit support.
1-877-363-1303
This number is for eligible TRICARE beneficiaries.
1-877-222-7336
This number supports patients using Accredo Specialty Pharmacy by Evernorth.
1-866-435-8451
Evernorth publishes this number for EnGuide Pharmacy provider support.
The current EnGuide Pharmacy address is:
4600 North Hanley Road, Suite C
St. Louis, MO 63134.
Express Scripts does not publish one universal consumer sales number.
Employer and health-plan sales relationships are handled through Evernorth and Express Scripts business channels.
1-800-282-2881
For online-account technical support:
1-800-711-5672
Express Scripts does not publish one universal public billing number for all members.
Billing, copay, prescription-price and benefit questions should be directed to the plan-specific number on the member ID card or:
1-800-282-2881
Express Scripts does not publish a universal regional-office telephone directory.
Express Scripts operates pharmacies, offices and service centers rather than a traditional branch network.
No single branch number applies to all locations.
For ordinary member assistance, Express Scripts directs callers to 1-800-282-2881 rather than a local St. Louis office number.
Express Scripts primarily provides U.S.-based pharmacy benefit services and does not publish one universal international member-support number.
1-800-282-2881
Express Scripts Pharmacy assistance and pharmacist access are available 24 hours a day, seven days a week.
Express Scripts no longer maintains a separate Investor Relations department because it is part of The Cigna Group.
The Cigna Group corporate number is:
+1 (860) 226-6000
Current SEC filings associate this number with The Cigna Group’s headquarters.
Express Scripts media matters are generally handled through Evernorth Health Services and The Cigna Group communications teams.
A universal Express Scripts consumer-facing press number is not published through its current Contact Us page.
Express Scripts does not publish one universal public HR number for outside job applicants.
Applicants should use The Cigna Group’s careers platform.
Not applicable.
Express Scripts is a pharmacy-benefit and healthcare-services business.
1-866-216-7096
Email: fraudtip@evernorth.com
This hotline is available 24/7 for suspected fraudulent activity.
For general prescription-benefit or Express Scripts Pharmacy assistance, call 1-800-282-2881. Express Scripts states that members can reach a patient care advocate or pharmacist 24 hours a day, seven days a week, with no need to wait for a voicemail callback. Members can also use the plan-specific number printed on the back of their prescription ID card, which may route them more directly to the correct benefits team.
Before calling, have your member ID card, prescription information, medication name and relevant claim details available. For an online-account or login issue, use 1-800-711-5672 instead. Medicare members should use 1-866-529-4917, while TRICARE beneficiaries should use 1-877-363-1303.
Express Scripts / Evernorth Health Services
One Express Way
St. Louis, MO 63121
United States
The Cigna Group’s current annual report identifies Evernorth Health Services corporate offices at and around One Express Way in St. Louis as a principal domestic office location.
One Express Way
St. Louis, Missouri 63121
United States
Express Scripts historically used this location as its principal executive offices before its acquisition by Cigna.
The Cigna Group
900 Cottage Grove Road
Bloomfield, CT 06002
United States
Corporate Phone: +1 (860) 226-6000
This is the current principal executive-office address of Express Scripts’ ultimate parent company.
Evernorth EnGuide Pharmacy
4600 North Hanley Road, Suite C
St. Louis, MO 63134
United States
Provider Phone: 1-866-435-8451
Fax: 1-866-219-1934
This location is specifically for EnGuide Pharmacy operations and should not be confused with Express Scripts corporate headquarters.
Express Scripts publishes the following address for certain prescription-claims records requests:
Express Scripts, Inc.
Claims Dept – Records/HQ21-06
8455 University Place Drive
St. Louis, MO 63121
United States
This is a specialized records-processing address rather than the company’s general corporate headquarters.
Before becoming part of Cigna, Express Scripts publicly reported:
One Express Way
St. Louis, MO 63121
as its principal executive offices, with telephone number:
314-996-0900.
The location remains associated with Evernorth Health Services operations, but current corporate ownership ultimately sits with The Cigna Group.
Members who experience a problem involving prescription coverage, home delivery, medication access, pharmacy claims, account access or customer service should first gather the relevant documentation. Useful information can include the member ID card, medication name, prescription number, pharmacy information, claim date and previous support reference numbers.
Review the telephone number on the back of your prescription ID card.Express Scripts states that members may have plan-specific contact numbers and support information available after signing in.
Call:
1-800-282-2881
Support is available 24 hours a day, seven days a week.Explain the problem and provide the relevant prescription or claim information.
If the complaint involves medication instructions, side effects or another clinical question, ask to speak with an Express Scripts pharmacist.Pharmacists are available 24/7.
Sign in to Express Scripts and open:
Help → FAQs & Contact Us
Express Scripts provides plan-specific contact options after login.
For website or online-account access problems, call:
1-800-711-5672
This line is available 24/7.
Save claim details, prescription information, emails and case numbers.Write down the date of each call and what the representative advised.
If the problem is not resolved, contact Express Scripts again and provide the existing complaint or case information.Explain what remains unresolved and what resolution you are seeking.
For Medicare:
1-866-529-4917
For TRICARE:
1-877-363-1303
For Accredo Specialty Pharmacy:
1-877-222-7336
For suspected fraudulent activity:
Fraud Hotline: 1-866-216-7096
Email: fraudtip@evernorth.com
This hotline operates 24/7.
For broader unresolved corporate correspondence:
Express Scripts / Evernorth Health Services
One Express Way
St. Louis, MO 63121
United States
Routine member complaints should normally remain within Patient Customer Service and plan-specific support before corporate escalation.
For an issue requiring ultimate parent-company escalation:
The Cigna Group
900 Cottage Grove Road
Bloomfield, CT 06002
United States
Corporate Phone: 860-226-6000
If a pharmacy-benefit issue remains unresolved, members may review the applicable health-plan grievance, insurance-regulatory, Medicare, TRICARE or other external complaint procedure.The correct process depends on the member’s health plan and the type of benefit involved.
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